DTHIB New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 897326-30-6 | Cat. No. | BCP40269 |
| Name | DTHIB | ||
| Synonyms | |||
| SMILES | O=C(NC1=CC=C(F)C=C1)NC2=CC=C(Cl)C([N+]([O-])=O)=C2 | ||
| Chemical Name | |||
| Formula | C13H9ClFN3O3 | M. Wt | 309.68 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM. DTHIB physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. DTHIB robustly inhibited the HSF1 cancer gene signature and prostate cancer cell proliferation. In addition, it potently attenuated tumor progression in four therapy-resistant prostate cancer animal models, including an NEPC model, where it caused profound tumor regression. | ||
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