AST-1306
Data Sheet
For research use only. Not for human use.
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| CAS No. | 897383-62-9 | Cat. No. | BCP05802 |
| Name | AST-1306 | ||
| Synonyms | AST1306; AST 1306; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H18ClFN4O2 | M. Wt | 448.88 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AST1306 is a novel anilino-quinazoline compound, which inhibits the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST1306 was found to function as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. In vivo, AST1306 potently suppressed tumor growth in ErbB2-overexpressing adenocarcinoma xenograft and FVB-2/N(neu) transgenic breast cancer mouse models, but weakly inhibited the growth of EGFR-overexpressing tumor xenografts. | ||
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