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PF-2545920 Chemical Structure

PF-2545920

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP05602CAS No. ：898562-94-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 898562-94-2 Cat. No. BCP05602
Name PF-2545920
Synonyms PF 2545920;PF2545920;Mardepodect;
SMILES
Chemical Name
Formula C25H20N4O M. Wt 392.45
Purity 98% Storage Store at 4-8°C
Description PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.The PDE10A enzyme is expressed primarily in the brain, mostly in the striatum, nucleus accumbens and olfactory tubercle, and is thought to be particularly important in regulating the activity of dopamine-sensitive medium spiny neurons in the striatum which are known to be targets of conventional antipsychotic agents. n the conditioned avoidance response assay (CAR), PF-2545920 was active with an ED50 of 1 mg/kg. Administration of PF-2545920 to mice caused a dose dependent increase in striatal cGMP.
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