PIK-294
Data Sheet
For research use only. Not for human use.
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| CAS No. | 900185-02-6 | Cat. No. | BCP01970 |
| Name | PIK-294 | ||
| Synonyms | PIK 294;PIK294; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H23N7O2 | M. Wt | 489.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PIK-294 shows distinct patterns of isoform selectivity to inhibit different subsets of class I PI3K isoforms (p110β, p110δ, and p110γ) and exhibits low sensitivity to p110α with IC50 of 10 μM). The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity. | ||
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