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AT7519 HCl Chemical Structure

AT7519 HCl

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01950CAS No. ：902135-91-5Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 902135-91-5 Cat. No. BCP01950
Name AT7519 HCl
Synonyms AT 7519 HCl;AT-7519 HCl;AT7519 Hydrochloride ;AT-7519 Hydrochloride;AT 7519 Hydrochloride;
SMILES
Chemical Name
Formula C16H17Cl2N5O2.HCl M. Wt 418.71
Purity 98% Storage Store at 4-8°C
Description AT7519 HCl is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are serine/theronine kinases involved in regulation of the cell cycle and may be overexpressed in some types of cancer cells.
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