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UM164 Chemical Structure

UM164

Data Sheet For research use only. Not for human use.
Cat. No. :BCP29207CAS No. :903564-48-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 903564-48-7 Cat. No. BCP29207
Name UM164
Synonyms UM 164;UM-164;
SMILES O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=CC(NC(C5=CC=CC(C(F)(F)F)=C5)=O)=CC=C4C
Chemical Name
Formula C30H31F3N8O3S M. Wt 640.69
Purity 98% Storage Store at 4-8°C
Description UM164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β; inhibits c-Src autophosphorylation in TNBC cell lines, and shows potent antiproliferative activity with mean GI50 of 160 nM, alters the cell localization of c-Src in TNBC cells; completely inhibits p38 MAPK phosphorylation in SUM 149 cells at 50 nM; demonstrates potent anti-TNBC activity in xenograft models with limited in vivo toxicity.
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