MLN4924
Data Sheet
For research use only. Not for human use.
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| CAS No. | 905579-51-3 | Cat. No. | BCP01927 |
| Name | MLN4924 | ||
| Synonyms | TAK-924; TAK 924; TAK924;MLN-4924;MLN 4924; Pevonedistat; | ||
| SMILES | O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O | ||
| Chemical Name | |||
| Formula | C21H25N5O4S | M. Wt | 443.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pevonedistat, also known as MLN-4924 and TAK-924, is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). | ||
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