SKL2001

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP19782CAS No. ：909089-13-0Purity：98%

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CAS No.	909089-13-0	Cat. No.	BCP19782
Name	SKL2001
Synonyms	SKL-2001;SKL 2001; Wnt Agonist II;
SMILES
Chemical Name
Formula	C14H14N4O3	M. Wt	286.29
Purity	98%	Storage	Store at 4-8°C
Description	SKL2001 upregulated β-catenin responsive transcription by increasing the intracellular β-catenin protein level and inhibited the phosphorylation of β-catenin at residues Ser33/37/Thr41 and Ser45, which would mark it for proteasomal degradation, without affecting CK1 and GSK-3β enzyme activities. SKL2001 disrupted the Axin/β-catenin interaction, which is a critical step for CK1- and GSK-3β-mediated phosphorylation of β-catenin at Ser33/37/Thr41 and Ser45. The treatment of mesenchymal stem cells with SKL2001 promoted osteoblastogenesis and suppressed adipocyte differentiation, both of which were accompanied by the activation of Wnt/β-catenin pathway. SKL2001 did not affect either NF-κB or p53 reporter activity and inhibits β-catenin phosphorylation without affecting GSK-3β activity.