4SC-202
Data Sheet
For research use only. Not for human use.
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| CAS No. | 910462-43-0 | Cat. No. | BCP18522 |
| Name | 4SC-202 | ||
| Synonyms | 4SC202; 4SC 202; Domatinostat; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H21N5O3S | M. Wt | 447.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. | ||
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