Neratinib Maleate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 915942-22-2 | Cat. No. | BCP28677 |
| Name | Neratinib Maleate | ||
| Synonyms | HKI272; HKI 272; HKI-272; PB272; PB 272; PB-272; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C30H29ClN6O3.C4H4O4 | M. Wt | 673.11 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. | ||
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