Lexibulin dihydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 917111-49-0 | Cat. No. | BCP29189 |
| Name | Lexibulin dihydrochloride | ||
| Synonyms | Lexibulin 2Hcl;CYT-997 2Hcl;CYT-997 dihydrochloride; CYT997 dihydrochloride; CYT 997 dihydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H32Cl2N6O2 | M. Wt | 507.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Lexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo.Lexibulin, also known as CYT997, is a n orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. | ||
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