Riviciclib HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 920113-03-7 | Cat. No. | BCP13104 |
| Name | Riviciclib HCl | ||
| Synonyms | P276-00;P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H21Cl2NO5 | M. Wt | 438.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CDK (cyclin-dependent kinase) plays an important role in cell cycle progression via promoting the G1/S cell cycle transition. Many studies have shown that more CDKs are overexpressed in cancer cells than in normal cells, which explain the reason of cancer cells divide uncontrollably. The overexpression of CDK1/4/6 contributes to the phosphorylation of retinoblastoma protein (RB) via binding to CCND1 and results in the release of E2F transcription of genes required for cell cycle progression . P276-00 is a novel inhibitor of CDK (cyclin-dependent kinase) with the ability of arresting the cells in G1/S phase transcription. When tested with NSCLC cell lines, P276-00 showed high ability of inhibiting cell proliferate thus decreased the colony forming potential via blocking cell cycle . In head and neck squamous carcinoma cell line (FaDu, Detroits-562, SCC-25), treated with P276-00 for 12 hours could significantly inhibit cell ability with IC50 value ranging from 0.8 to 1.7 uM for different | ||
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