AdipoRon New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 924416-43-3 | Cat. No. | BCP08895 |
| Name | AdipoRon | ||
| Synonyms | SC-396658; | ||
| SMILES | C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4 | ||
| Chemical Name | |||
| Formula | C27H28N2O3 | M. Wt | 428.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AdipoRon is a potent and selective adiponectin receptor agonist. AdipoRon attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon may be a promising therapeutic approach for the treatment of obesity-related disease. | ||
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