Radotinib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 926037-48-1 | Cat. No. | BCP12554 |
| Name | Radotinib | ||
| Synonyms | IY-5511;IY5511;IY 5511;Supect; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H21F3N8O | M. Wt | 530.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Radotinib is a BCR-ABL1 specific 2nd-generation tyrosine kinase inhibitor. According to recently conducted in vitro kinase assays, the IC50 value for radotinib against wild-type BCR-ABL1 kinase was 34 nM, which is relatively lower compared with the IC50 levels of c-kit (1,324 nM), PDGFR (PDGFRα, 75.5 nM; PDGFRβ, 130 nM) and src (>2,000 nM). Also, radotinib effectively inhibited the proliferation of common mutant clones of BCR-ABL1, with the exception of T315I. In an off-target kinase assay to assess safety, DDR, EPHB, LYN, and PDGFR kinases were inhibited below the 180 nM level. | ||
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