RAF265

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02408CAS No. ：927880-90-8Purity：98%

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CAS No.	927880-90-8	Cat. No.	BCP02408
Name	RAF265
Synonyms	CHIR-265;RAF 265;RAF-265;CHIR265;CHIR 265;
SMILES
Chemical Name
Formula	C24H16F6N6O	M. Wt	518.43
Purity	98%	Storage	Store at 4-8°C
Description	RAF265 inhibits C-Raf, wild type B-Raf and mutant (V600E) B-Raf. RAF265 effectively block phosphorylation of Raf's downstream substrates MEK and ERK in cells and also kill melanoma and colorectal cancer cell lines harboring B-Raf mutations independent of PTEN mutation status. Raf kinase inhibition by RAF265 in mutant B-Raf melanoma cell lines causes cell cycle arrest and induces apoptosis, mimicking the effect of Raf RNAi in these cells. RAF265 also potently inhibits the phosphorylation of VEGFR2 and proliferation of VEGF-stimulated hMVEC.In HT29 and MDAMB231 cells, RAF265 shows inhibitory activity with IC20 of 1 to 3 μM and IC50 of 5 to 10 μM, respectively. While RAF265 leads to a significant decrease in clonogenic survival in all tested cell lines, which means that RAF265 induces a dominant effect on clonogenic survival. Addition of RAF265 to RAD001 in HCT116 cells could lead to moderately decreased AKT, S6 protein, and 4EBP1 phosphorylation.Raf265 markedly reduces the protein level