Pracinostat

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02073CAS No. ：929016-96-6Purity：98%

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CAS No.	929016-96-6	Cat. No.	BCP02073
Name	Pracinostat
Synonyms	SB939; SB-939; SB 939;
SMILES
Chemical Name
Formula	C20H30N4O2	M. Wt	358.48
Purity	98%	Storage	Store at 4-8°C
Description	SB939 has a 100-fold greater selectivity for HDACs than for Zn-binding non-HDAC enzymes, receptors, and ion channels. SB939 is a potent inhibitor of HDAC class I isoenzymes, HDAC1, HDAC2, HDAC3 and HDAC8 with the IC50 values ranging from 43 nM to 140 nM. SB939 inhibits HDAC class II isoenzymes , HDAC4, HDAC5, HDAC7, HDAC9 and HDAC10 significantly with the IC50 values ranging from 40 nM to 137 nM, with the exception of HDAC6 which shows IC50 of 1008 nM. It markedly inhibits HDAC11 of the HDAC class IV enzymes with IC50 of 93 nM, but shows no inhibitory activity against SIRT 1 of the class III HDACs. SB939 shows significant antiproliferative activity against a wide variety of tumor cell lines, especially Leukemia cells and cutaneous T-cell Lymphoma cells with IC50 values ranging from 50 nM (H9 cells) to 170 nM (HEL92.1.7 cells).