IOX2

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06141CAS No. ：931398-72-0Purity：98%

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CAS No.	931398-72-0	Cat. No.	BCP06141
Name	IOX2
Synonyms	IOX 2;IOX-2;
SMILES
Chemical Name
Formula	C19H16N2O5	M. Wt	352.34
Purity	98%	Storage	Store at 4-8°C
Description	IOX2 potently inhibits PHD2 (IC50 of 21 nM) with over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s <100 μM). IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM.Hypoxia Inducible Factor (HIF) is regulated by the hydroxylation of prolyl residues in oxygen-dependent degradation domains in the HIF-1α subunit, which mark it for degradation by the proteosome. 1,2 HIF prolyl hydroxylation is catalyzed by prolyl hydroxylase domain enzymes (PHD1, 2, and 3), members of the Fe(II) and 2-oxoglutarate (2OG) oxygenase family. They require dioxygen as a cosubstrate, thus acting as the hypoxia-sensing component of the HIF system. The activity of PHD is suppressed by hypoxia, increasing both the abundance and activity of the HIF transcriptional complex.