XL-147

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15312CAS No. ：934526-89-3Purity：98%

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CAS No.	934526-89-3	Cat. No.	BCP15312
Name	XL-147
Synonyms	SAR245408;XL 147;XL147;SAR-245408;SAR 245408;Pilaralisib;
SMILES
Chemical Name
Formula	C25H25ClN6O4S	M. Wt	541.02
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: XL147 binds in an ATP-competitive and reversible manner, yet is highly selective against a panel of >130 human protein kinases. In cellular assays, XL147 antagonizes the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) resulting in inhibition of phosphorylation of several downstream effectors of PI3K including Akt, ribosomal S6 kinase, and ribosomal S6 protein [1].Compared with XL147 alone, the combination exhibited a superior antitumor effect against trastuzumab-resistant tumor xenografts. Furthermore, treatment with XL147 and trastuzumab reduced the cancer stem-cell (CSC) fraction within trastuzumab-resistant cells both in vitro and in vivo. in vivo: SAR245408 induced significant differences in EFS distribution compared to control in 29 of 37 (79%) of solid tumor xenografts and in two of seven (29%) ALL. Xenografts. SAR245408 induced tumor growth inhibition meeting criteria for intermediate EFS T/C activity (EFS T/C?>?2) in 4 of 37 (11%) so