Ibrutinib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02558CAS No. ：936563-96-1Purity：98，EE 95%

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Nat Commun. 2015; 6: 7360.

CAS No.	936563-96-1	Cat. No.	BCP02558
Name	Ibrutinib
Synonyms	PCI32765;Ibrutinib;PCI 32765;
SMILES
Chemical Name
Formula	C25H24N6O2	M. Wt	440.5
Purity	98，EE 95%	Storage	Store at 4-8°C
Description	Ibrutinib shows the potent and irreversible inhibitory effect and selectivity for Btk enzymatic activity. In BCR pathway-activated DOHH2 cell line, Ibrutinib inhibits autophosphorylation of Btk, phosphorylation of Btk's physiological substrate PLCγ, and phosphorylation of further downstream kinase, ERK with IC50 of 11 nM, 29 nM and 13 nM, respectively.Ibrutinib exhibits a significant dose-dependent and time-dependent induction of cytotoxicity in chronic lymphocytic leukemia (CLL) cells. In addition, Ibrutinib induces cell death depending on caspase pathway activation and antagonizes the ability of CLL cells to proliferate after TLR signaling. A recent study shows that Ibrutinib inhibits BCR-activated primary B cell proliferation with IC50 of 8 nM and results in inhibition of TNFα, IL-1β and IL-6 production in primary monocytes with IC50 of 2.6 nM, 0.5 nM and 3.9 nM, respectively.