OSI-027
Data Sheet
For research use only. Not for human use.
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| CAS No. | 936890-98-1 | Cat. No. | BCP02613 |
| Name | OSI-027 | ||
| Synonyms | OSI027;OSI 027; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H22N6O3 | M. Wt | 406.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | OSI-027 shows the selective and ATP competitive inhibition activities against mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. In addition, OSI-027 inhibits mTOR signaling of phospho-4E-BP1 with an IC50 of 1 μM in cell-based assays.OSI-027 exhibits anti-proliferative activities against several acute leukemia cell lines of myeloid/megakaryocytic origin in a dose-dependent manner, including U937, KG-1, KBM-3B, ML-1, HL-60, and MEG-01 cells.A recent study shows that inhibition of mTORC1/2 by OSI-027 effectively suppresses phosphorylation of Akt (S473) and cell proliferation in breast cancer cells. | ||
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