Ku-0063794

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01931CAS No. ：938440-64-3Purity：98%

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CAS No.	938440-64-3	Cat. No.	BCP01931
Name	Ku-0063794
Synonyms	KU 0063794;KU0063794; KU63794; KU 63794; KU-63794;
SMILES
Chemical Name
Formula	C25H31N5O4	M. Wt	465.56
Purity	98%	Storage	Store at 4-8°C
Description	Compared with the mTOR inhibitor PP242, KU-0063794 exhibits higher specificity for mTOR, as being inactive against PI3Ks or 76 other kinases. In HEK-293 cells, KU-0063794 at 30 nM is sufficient to rapidly ablate S6K1 activity by blocking the phosphorylation of the hydrophobic motif (Thr389) and subsequently the phosphorylation of the T-loop residue (Thr229). In case of IGF1 stimulation of serum-starved HEK-293 cells, 300 nM of KU-0063794 is needed to inhibit the S6K1 activity by ~90%. KU-0063794 at 100-300 nM also completely inhibits the amino-acid-induced phosphorylation of S6K1 and S6 protein. Similar to S6K1, KU-0063794 inhibits the phosphorylation of mTORC1 at Ser2448 and mTORC2 at Ser2481 in a dose-dependent and time-dependent manner. In the presence of serum or following IGF1 stimulation, KU-0063794 induces a dose-dependent inhibition of the activity and phosphorylation of Akt at Ser473 and unexpected Thr308 as well as the phosphorylation of the Akt substrates PRAS40 at Thr246, G