GSK1016790A
Data Sheet
For research use only. Not for human use.
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| CAS No. | 942206-85-1 | Cat. No. | BCP20201 |
| Name | GSK1016790A | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H32Cl2N4O6S2 | M. Wt | 655.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In vitro: In HeLa cells transiently transfected with TRPV4 (HeLa-TRPV4). GSK101 (10 nM) causes a TRPV4 specific Ca2+ influx in HeLa-TRPV4 cells, but not in control transfected cells, which can be inhibited by ruthenium red and Ca2+-free medium more significantly at the early stage of the activation rather than the late stage, reflecting apparent partial desensitization.In vivo: Concomitant activation of NO and EDHF by TRPV4 channel agonist GSK1016790A (GSK) in the rat pulmonary artery. | ||
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