PHA-767491 HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 942425-68-5 | Cat. No. | BCP28863 |
| Name | PHA-767491 HCl | ||
| Synonyms | PHA 767491 Hydrochloride; PHA 767491 HCl ; PHA767491 HCl ;PHA767491; PHA-767491; PHA 767491; CAY10572; CAY-10572; CAY 10572; | ||
| SMILES | O=C1C2=C(NC(C3=CC=NC=C3)=C2)CCN1.[H]Cl | ||
| Chemical Name | |||
| Formula | C12H12ClN3O | M. Wt | 249.7 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PHA-767491, also known as CAY10572, is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. PHA-767491 in combination with 5-FU exhibited much stronger cytotoxicity and induced significant apoptosis manifested by remarkably increased caspase 3 activation and poly(ADP-Ribose) polymerase fragmentation in HCC cells. PHA-767491 directly counteracted the 5-FU-induced phosphorylation of Chk1, a substrate of Cdc7; and decreased the expression of the anti-apoptotic protein myeloid leukemia cell 1, a downstream target of Cdk9. | ||
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