Buparlisib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02425CAS No. ：944396-07-0Purity：98%

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CAS No.	944396-07-0	Cat. No.	BCP02425
Related Products	1312445-63-8（Buparlisib Hydrochloride）
Name	Buparlisib
Synonyms	NVPBKM120; NVP BKM120;NVP-BKM120;NVP-BKM-120;BKM120;BKM-120;BKM 120;
SMILES
Chemical Name
Formula	C18H21F3N6O2	M. Wt	410.39
Purity	98%	Storage	Store at 4-8°C
Description	Buparlisib is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases with potential antineoplastic activity. Buparlisib specifically inhibits class I PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.