AMG-900

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02552CAS No. ：945595-80-2Purity：98%

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CAS No.	945595-80-2	Cat. No.	BCP02552
Name	AMG-900
Synonyms	AMG 900;AMG900;
SMILES
Chemical Name
Formula	C28H21N7OS	M. Wt	503.58
Purity	98%	Storage	Store at 4-8°C
Description	AMG 900 is a novel class of ATP-competitive phthalazinamine small molecule inhibitors of aurora kinases. In HeLa cells, AMG 900 inhibits autophosphorylation of aurora-A and -B as well as phosphorylation of histone H3 on Ser, a proximal substrate of aurora-B. The predominant cellular response of tumor cells to AMG 900 treatment is aborted cell division without a prolonged mitotic arrest, which ultimately results in cell death. AMG 900 inhibits the proliferation of 26 tumor cell lines, including cell lines resistant to the antimitotic drug paclitaxel and to other aurora kinase inhibitors (AZD1152, MK-0457, and PHA-739358), at low nanomolar concentrations (about 2- 3 nM). Furthermore, AMG 900 is active in an AZD1152-resistant HCT116 variant cell line that harbors an aurora-B mutation (W221L).