FPS-ZM1

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16845CAS No. ：945714-67-0Purity：98%

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CAS No.	945714-67-0	Cat. No.	BCP16845
Name	FPS-ZM1
Synonyms	FPS ZM1;FPSZM1; FPS-ZM 1; FPS ZM-1; FPSZM 1;
SMILES	ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1
Chemical Name
Formula	C20H22ClNO	M. Wt	327.85
Purity	98%	Storage	Store at 4-8°C
Description	FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end products (RAGE; Ki = 25 nM).1 It blocks the binding of amyloid β (Aβ) protein to RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells.1 FPS-ZM1 is functional in mice when administered intraperitoneally and penetrates the blood-brain barrier (BBB), inhibiting β-secretase activity, Aβ production, microglia activation, and neuroinflammation.1,2 FPS-ZM1 is used to elucidate the role of RAGE-mediated signaling in diverse physiological processes in vivo, including cancer tumor growth, angiogenesis, and metastasis, as well as BBB damage, edema, and inflammation after intracerebral hemorrhage.3,4