AZD1152

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01734CAS No. ：957881-03-7Purity：98%

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CAS No.	957881-03-7	Cat. No.	BCP01734
Name	AZD1152
Synonyms	AZD-1152;AZD1152;Barasertib;AZD1152-HQPA;
SMILES
Chemical Name
Formula	C26H31FN7O6P	M. Wt	587.54
Purity	98%	Storage	Store at 4-8°C
Description	AZD1152 displays >3000-fold selectivity for Aurora B as compared with Aurora A which has an IC50 of 1.368 μM. AZD1152 has even less activity against 50 other serine-threonine and tyrosine kinases including FLT3, JAK2, and Abl. AZD1152 inhibits the proliferation of hematopoietic malignant cells such as HL-60, NB4, MOLM13, PALL-1, PALL-2, MV4-11, EOL-1, THP-1, and K562 cells with IC50 of 3-40 nM, displaying ~100-fold potency than another Aurora kinase inhibitor ZM334739 which has IC50 of 3-30 μM. AZD1152 inhibits the clonogenic growth of MOLM13 and MV4-11 cells with IC50 of 1 nM and 2.8 nM, respectively, as well as the freshly isolated imatinib-resistant leukemia cells with IC50 values of 1-3 nM, more significantly compared with bone marrow mononuclear cells with IC50 values of >10 nM. AZD1152 induces accumulation of cells with 4N/8N DNA content, followed by apoptosis in a dose- and time-dependent manner.