Daprodustat

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16766CAS No. ：960539-70-2Purity：98%

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CAS No.	960539-70-2	Cat. No.	BCP16766
Name	Daprodustat
Synonyms	GSK1278863;GSK-1278863;GSK 1278863;
SMILES
Chemical Name
Formula	C19H27N3O6	M. Wt	393.43
Purity	98%	Storage	Store at 4-8°C
Description	GSK1278863 is a novel HIF-PHI, is a novel small molecule agent which has the ability to stimulate the HIF pathway and therefore, it is under investigation for treatment of anemia associated with chronic kidney disease. GSK1278863 is an investigative drug under investigation for treatment of anemia associated with chronic kidney disease.GSK1278863 is an orally administered small-molecule PHI, stabilizes HIF, which is known to modulate HIF-controlled gene products including EPO. GSK1278863 induced an effective EPO response and stimulated non-EPO mechanisms for erythropoiesis in anemic non-dialysis-dependent and dialysis-dependent patients with CKD. GSK1278863 is an orally-active small molecule agent that inhibits hypoxia-inducible factor (HIF) prolyl-4-hydroxylases (PHDs) that is currently in clinical development for the treatment of anemia associated with chronic kidney disease (CKD).