CPI-455 HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | CPI-455HCl | Cat. No. | BCP25488 |
| Name | CPI-455 HCl | ||
| Synonyms | CPI 455 HCl ;CPI455 HCl; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H14N4O.HCl | M. Wt | 314.77 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CPI-455 is a potent and selective inhibitor of KDM5 demethylases which reduces survival of drug-tolerant cancer cells. CPI-455 mediated KDM5 inhibition, elevated global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents. Pretreatment of cancer cells with a KDM5-specific inhibitor results in the ablation of a subpopulation of cancer cells that can serve as the founders for therapeutic relapse. | ||
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