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Product Name:GDC-0941 
Cas No.:957054-30-7;957054-33-0 (dimethanesulfonate) 
Apperarnce:white solid 
Supply ability:1KG 

M.Wt: 513.64
Formula: C23H27N7O3S2
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years

10G in stock


1.The IC50 values of GDC0941 for the inhibition of phosphorylation of Ser473 on AKT in IGROV-1 cells following 2- or 8-hour exposure were 18 ± 1 and 38 ± 13 nmol/L, respectively.

2.GDC-0941 Causes Sustained Inhibition ofthe Phosphatidylinositide 3-Kinase Pathway in U87MG Glioblastoma Xenografts

3.GDC-0941 was much less potent on mTOR and DNA-PK. Importantly, the activity of GDC-0941 against the panel of human tumor cell lines was generally similar to that of PI-103, suggesting that high potency against mTOR and/or DNA-PK was not essential for the inhibition of cell proliferation. In addition,GDC-0941 potently inhibited growth of activated human endothelial cells, suggesting potential for antiangiogenic activity, as we previously reported for PI-103.

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