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Gemcitabine Hydrochloride
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Product Name:Gemcitabine Hydrochloride 
Cas No.:122111-03-9 

M.Wt: 299.7

 Formula: C9H11F2H3O4

Solubility: Soluble in water

Purity: >99%

Storage: -20℃ 2 years

Surprise price with large stock
High quality with HPLC & NMR Chart
Fast delivery about 4-5 working days


Gemcitabine(dFdC) is a new pyrimidine antimetabolite which has shown good clinical activity in pancreatic, breast, ovarian, non-small-cell lung, and bladder cancer. As a prodrug, Gemcitabine requires intracellular phosphorylation to the active Gemcitabine-nucleotides for activation. Both gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP) contribute to inhibition of DNA synthesis and thereby determine antitumor activity. Gemcitabine diphosphate effectively inhibits ribonucleotide reductase inducing a depletion of cellular deoxynucleotides (dNTP). On the one hand this will inhibit DNA synthesis by lack of sufficient DNA precursors. On the other hand, dCTP depletion stimulates Gemcitabine phosphorylation and enhances incorporation of Gemcitabine nucleotides into DNA. Additionally, dFdCTP-mediated inhibition of dCMP deaminase is responsible for the prolonged cellular half-life of the active dFdCTP, an effect which presumably explains the good activity of Gemcitabine in solid tumors. Gemcitabine further acts as an effective inhibitor of DNA repair which was specifically demonstrated with regard to DNA damage induced by radiation or alkylating agents. Its potential as a repair inhibitor and its comparatively low toxicity profile make Gemcitabine a promising agent for combination treatments.

1. Banerjee S, et al. Cancer Res. 2009 Jul 1;69(13):5575-83. Epub 2009 Jun 23. 2. Chun PY, et al. Cancer Res. 2006 Jan 15;66(2):981-8.

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