Product Pathways
BCP0006 GSK1904529A
GSK1904529A is a selective inhibitor of IGF-IR and IR with IC50 of 27 nM and 25 nM, respectively.
BCP0012 ABT-869(Linifanib)
ABT-869 is multi-targeted in that it is a potent inhibitor of all members of the VEGF and PDGF receptor families.
BCP0080 NVP-ADW742
NVP-ADW742 is an ATP-competitive inhibitor that inhibits IGF-IR autophosphorylation with a cellular IC50 of 0.1 to 0.2 umol/L, which is 16-fold lower than that of the insulin receptor.
BCP0085 OSI-906(Linsitinib)
OSI-906 is a potent, selective orally active inhibitor of the insulin-like growth factor-1 receptor (IGF-1R).
BCP0200 BMS754807
BMS-754807 is an IGF-1R inhibitor.
BCP0425 BMS536924
BMS-536924 is a small molecule ATP-competitive IGF-IR kinase inhibitor with with an IC50 of 80 nM.
BCP000739 NVP-AEW541
NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative highly selective against IGF-IR.
BCP000866 OSI906,Linsitinib
OSI-906 is a potential first-in-class selective small molecule
BCP000973 BMS554417
BCP000974 GSK1838705A
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