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BCP0010 ABT-263(Navitoclax)
ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins .
BCP0011 ABT737
ABT737,a selective inhibitor of BCL-2, in small cell lung cancer.
BCP0059 HA14-1
Cell-permeable inhibitor of Bcl-2 protein (IC50 ~ 9 µM).
BCP0083 Obatoclax Mesylate
Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.
BCP0128 TW-37
TW-37 binds to the BH3 binding groove in Bcl-2 protein competing with BH3 peptides derived from Bid, Bim, and Bad proteins.
BCP0006811 ABT-199
ABT-199 is a potent and selective inhibitor of B-cell lymphoma-2 (BCL-2) family proteins, currently in clinical trials.
BCP0007775 BAM-7
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