Product Pathways
BCP0164 LY450139(Semagacestat)
Semagacestat(LY450139) is a γ-secretase blocker with an IC50 of 15 nM.
BCP0490 Dibenzazepine
YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch, respectively.
BCP0492 γ-Secretase Inhibitor BZ
Very potent and cell-permeable inhibitor of γ-secretase.
BCP000577 Merck γ-secretase modulator
BCP000580 BMS708163
BMS-708163 is a potent and selective γ-secretase inhibitor
BCP000598 MK-0752
MK-0752 is a potent gamma secretase inhibitor in clinical development (IC50 50 nM).
BCP000650 DAPT
DAPT,Inhibitor of γ-secretase.
BCP000863 LY411575
BCP000890 YO-01027
YO-01027 is a dipeptidic gamma-secretase inhibitor with IC50 of 2.6 and 2.9 nM for the proteolysis of APPL and Notch
BCP000925 RO4929097
RO4929097 is a potent and selective small molecule inhibitor of ?-secretase (IC50=4nM), producing inhibitory activity of Notch signaling in tumor cells. It inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot.
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