GSK2110183
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1047634-63-8 | Cat. No. | BCP15122 |
| Name | GSK2110183 | ||
| Synonyms | GSK-2110183;GSK 2110183; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H18Cl3FN4OS | M. Wt | 463.78 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK2110183 showed concentration-dependent effect on multiple AKT substrate phosphorylation levels, including GSK3β, PRAS40, FOXO and Caspase 9 in BT474 (breast; ERBB2+, PIK3CA K111N) and LNCaP (prostate; PTEN null). Mice bearing BT474 breast tumor xenografts were dosed orally with either vehicle or GSK2110183 at 10, 30 or 100 mg/kg daily for 21 days which resulted in 8, 37 and 61% TGI, respectively. Similarly, mice treated with GSK2110183 at 10, 30 and 100 mg/kg resulted in 23, 37 and 97% TGI, respectively, of SKOV3 xenografts. | ||
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