KC7F2

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16036CAS No. ：927822-86-4Purity：98%

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CAS No.	927822-86-4	Cat. No.	BCP16036
Name	KC7F2
Synonyms
SMILES
Chemical Name
Formula	C16H16Cl4N2O4S4	M. Wt	570.38
Purity	98%	Storage	Store at 4-8°C
Description	KC7F2 is the second HIF-1α inhibitor. KC7F2 is shown to inhibit the proliferation of cancer cells, an effect that is increased in hypoxia, while non-tumor cells are less sensitive. KC7F2 decreases HIF-1α levels by downregulating HIF-1α protein synthesis. KC7F2 markedly inhibits HIF-mediated transcription in cells derived from different tumor types, including glioma, breast and prostate cancers and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevents the activation of HIF-target genes such as Carbonic Anhydrase IX, Matrix Metalloproteinase 2 (MMP2), Endothelin 1 and Enolase 1. KC7F2 works through the down-regulation of HIF-1α protein synthesis, an effect accompanied by the suppression of the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K), key regulators of HIF-1α protein synthesis.