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Avagacestat Chemical Structure

Avagacestat

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01770CAS No. :1146699-66-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1146699-66-2 Cat. No. BCP01770
Name Avagacestat
Synonyms BMS-708163;BMS708163;BMS 708163;
SMILES O=C(N)[C@H](N(CC1=CC=C(C2=NOC=N2)C=C1F)S(=O)(C3=CC=C(Cl)C=C3)=O)CCC(F)(F)F
Chemical Name
Formula C20H17ClF4N4O4S M. Wt 520.89
Purity 98% Storage Store at 4-8°C
Description Avagacestat, also known as BMS-708163, is an oral GSI designed for selective inhibition of Aβ synthesis currently in development for the treatment of mild to moderate and predementia AD. In addition to the desired effect on Aβ synthesis, GSIs affect Notch processing, which is thought to mediate some toxic adverse effects reported with this drug class.
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