PD184352

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01791CAS No. ：212631-79-3Purity：98%

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CAS No.	212631-79-3	Cat. No.	BCP01791
Name	PD184352
Synonyms	CI-1040;CI1040;CI 1040;PD-184352;PD 184352;
SMILES
Chemical Name
Formula	C17H14ClF2IN2O2	M. Wt	478.66
Purity	98%	Storage	Store at 4-8°C
Description	CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26, BX-PC3 pancreatic, A431 cervical, HT-29 colon, ZR-25-1 breast and SKOV-3 ovarian carcinomas. CI-1040 treatment doesn't inhibit the phosphorylation of Jun kinase, p38 kinase or Akt, indicating CI-1040 specifically targets MEK. Inhibition of MAPK activation by CI-1040 prevents cell cycle progression and induces a G1 block. The IC50 for inhibition of MEK1 by CI-1040 is 0.3 μM, 15-fold higher than the concentration required to inhibit the EGF-induced activation of ERK2 in Swiss 3T3 cells. These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1, and not by blocking its activity. 2 nM PD184352 inhibits the activation of MKK1 in Swiss 3T3 cells by 50%, while over 100-fold concentration of CI-1040 inhibits MEK1 in vitro. PD184352 also inhibits the Raf-catalysed phosphorylation of MEK1 without any effect on the Raf-catalysed phosphorylation of myelin basic