BIBR-1532
Data Sheet
For research use only. Not for human use.
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| CAS No. | 321674-73-1 | Cat. No. | BCP01934 |
| Name | BIBR-1532 | ||
| Synonyms | BIBR1532;BIBR 1532; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H17NO3 | M. Wt | 331.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BIBR 1532 exhibits an non-competitive inhibitory effect on telomerase activity. [1] In JVM13 leukemia cell line, BIBR 1532 shows an antiproliferative effect in a dose-dependent range with IC50 of 52 μM, and similar results are also observed in other leukemia cell lines including Nalm-1, HL-60, and Jurkat. In addition, BIBR 1532 results in a direct antiproliferative effect on acute myeloid leukemia (AML) with IC50 of 56 μM without affecting the proliferative capacity of normal hematopoietic progenitor cells. BIBR 1532 (2.5 μM) reduces colony-forming ability, and induces telomere length shortening as well as chemotherapeutic sensitization by inhibiting telomerase activity in MCF-7/WT and melphalan-resistant MCF-7/MlnR cell lines. In T-cell prolymphocytic leukemia (T-PLL), BIBR 1532 shows selective cytotoxic effects in a dose-dependent manner and BIBR 1532-treated cells also demonstrates nuclear condensation and formation of apoptotic bodies morphologically compatible with apoptosis. A re | ||
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