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Gedatolisib Chemical Structure

Gedatolisib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01986CAS No. ：1197160-78-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1197160-78-3 Cat. No. BCP01986
Name Gedatolisib
Synonyms PKI-587;PKI587;PKI 587;PF 05212384;PF05212384;PF-05212384;
SMILES O=C(NC1=CC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)NC5=CC=C(C(N6CCC(N(C)C)CC6)=O)C=C5
Chemical Name
Formula C32H41N9O4 M. Wt 615.73
Purity 98% Storage Store at 4-8°C
Description Gedatolisib, also known as PKI-587 and PF-05212384, is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Upon intravenous administration, PI3K/mTOR kinase inhibitor PKI-587 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.
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