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Foretinib Chemical Structure

Foretinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02231CAS No. ：849217-64-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 849217-64-7 Cat. No. BCP02231
Name Foretinib
Synonyms XL880;GSK1363089;GSK089;EXEL-2880;XL-880;GSK 1363089;GSK 089;EXEL2880;XL 880;GSK-1363089;GSK-089;EXEL2880;
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Chemical Name
Formula C34H34F2N4O6 M. Wt 632.67
Purity 98% Storage Store at 4-8°C
Description XL880 inhibits HGF receptor family tyrosine kinases with IC50 values of 0.4 nM for Met and 3 nM for Ron. XL880 also inhibits KDR, Flt-1, and Flt-4 with IC50 values of 0.9 nM, 6.8 nM and 2.8 nM, respectively. XL880 inhibits colony growth of B16F10, A549 and HT29 cells with IC50 of 40 nM, 29 nM and 165 nM, respectively. A recent study indicates XL880 affects cell growth differently in gastric cancer cell lines MKN-45 and KATO-III. XL880 inhibits phosphorylation of MET and downstream signaling molecules in MKN-45 cells, while targets GFGR2 in KATO-III cells.
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H-NMR HPLC
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