GSK2126458
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 1086062-66-9 | Cat. No. | BCP02252 |
| Name | GSK2126458 | ||
| Synonyms | GSK-2126458;GSK 2126458; Omipalisib; | ||
| SMILES | COC1=NC=C(C=C1NS(C2=CC=C(C=C2F)F)(=O)=O)C3=CC=C(C4=C3)N=CC=C4C5=CN=NC=C5 | ||
| Chemical Name | |||
| Formula | C25H17F2N5O3S | M. Wt | 505.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK2126458 potently inhibits the activity of common activating mutants of p110α (E542K, E545K, and H1047R) found in human cancer with Ki of 8 pM, 8 pM and 9 pM, respectively.GSK2126458 causes a significant reduction in the levels of pAkt-S473 with remarkable potency in T47D and BT474 cells with IC50 of 0.41 nM and 0.18 nM, respectively. Furthermore, GSK2126458 leads to a G1 cell cycle arrest and produces the inhibitory effect on cell proliferation in a large panel of cell lines, including T47D and BT474 breast cancer lines with IC50 of 3 nM and 2.4 nM, respectively. | ||
Recommend Products
More >
-
-
PI3K/mTOR Inhibitor-2
Cat. No.：BCP48401
No.：1848242-58-9
Product Details -
-
Disitertide
Cat. No.：BCP46789
No.：272105-42-7
Product Details -
IHMT-PI3Kδ-372
Cat. No.：BCP46775
No.：2429889-62-1
Product Details -
Gilmelisib
Cat. No.：BCP46378
No.：1845777-61-8
Product Details -
-
ETP-45658
Cat. No.：BCP45165
No.：1198357-79-7
Product Details -
-
Panulisib
Cat. No.：BCP44105
No.：1356033-60-7
Product Details -
Parsaclisib hydrochloride
Cat. No.：BCP42656
No.：1995889-48-9
Product Details -
-
-
-
Nemiralisib
Cat. No.：BCP38658
No.：1254036-71-9
Product Details -
TGR1202 racemate
Cat. No.：BCP24685
No.：1532533-65-5
Product Details -
Umbralisib tosylate
Cat. No.：BCP24684
No.：1532533-72-4
Product Details -
Umbralisib R-enantiomer
Cat. No.：BCP24683
No.：1532533-69-9
Product Details -
Umbralisib sulfate
Cat. No.：BCP24681
No.：1532533-75-7
Product Details -
GSK2292767
Cat. No.：BCP24323
No.：1254036-66-2
Product Details
Tags:GSK2126458 supplier,GSK2126458 purchase,GSK2126458 manufacturer,GSK2126458 distributor,GSK2126458 cost,GSK2126458 buy,GSK2126458 for sale