VU0357121
Data Sheet
For research use only. Not for human use.
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| CAS No. | 433967-28-3 | Cat. No. | BCP04788 |
| Name | VU0357121 | ||
| Synonyms | VU0 357121;VU-0357121; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H17F2NO2 | M. Wt | 305.32 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. | ||
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