Nutlin-3a
Data Sheet
For research use only. Not for human use.
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Publications Citing of Biochempartner's Nutlin-3a
| CAS No. | 675576-98-4 | Cat. No. | BCP05161 |
| Name | Nutlin-3a | ||
| Synonyms | Nutlin 3a;Nutlin3a; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C30H30Cl2N4O4 | M. Wt | 581.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Nutlin-3a displaces p53 from the binding pocket of MDM2 and thereby releases p53 from inhibition and proteasomal degradation, leading to induction of its downstream targets, cell cycle arrest, and apoptosis. Seven days of incubation with 10 μM nutlin-3a led to >90% inhibition of NIH3T3 cells’ growth[1]. Nutlin-3a stabilizes and activates p53, and induces p21 expression in a dose-dependent manner[1]. Nutlin-3a effectively depletes the S-phase compartment to 0.2-2% and increases the G1- and G2/M-phase compartments[1]. Nutlin-3a induces apoptosis in ~60% of SJSA-1 and MHM cells after 40 h, which increased further after 60 h (85% and 65%, respectively). | ||
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