Nutlin-3b

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP05162CAS No. ：675576-97-3Purity：98%

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CAS No.	675576-97-3	Cat. No.	BCP05162
Name	Nutlin-3b
Synonyms	Nutlin 3b;Nutlin3b;
SMILES
Chemical Name
Formula	C30H30Cl2N4O4	M. Wt	581.49
Purity	98%	Storage	Store at 4-8°C
Description	Nutlin-3b is useful as a negative control s for non-MDM2-related cellular activities. Nutlin-3a induces the expression of MDM2 and p21 (but not p53) only in cells with wild-type p53. Nutlin-3b has no effect regardless of the p53 status of the cells. Only the active enantiomer Nutlin-3a shows a potent antiproliferative activity and clear separation of potency between the cells harboring wild-type p53 and those harboring mutant p53. The potency of Nutlin-3b is much lower in the wild-type p53 cells and nearly identical to the potency of Nutlin-3a against the mutant p53 cells. After 48 hours of exposure to the Nutlin-3a, 45% of the cell population became TUNEL positive, but cells treated with the Nutlin-3b are indistinguishable from the untreated controls.