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SL327 Chemical Structure

SL327

Data Sheet For research use only. Not for human use.
Cat. No. :BCP05310CAS No. :305350-87-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 305350-87-2 Cat. No. BCP05310
Name SL327
Synonyms SL-327;SL 327;
SMILES
Chemical Name
Formula C16H12F3N3S M. Wt 335.35
Purity 98% Storage Store at 4-8°C
Description SL-327 has been shown to block hippocampal LTP via inhibition of the MAPK/ERK cascade, which prevents CREB and Elk-1 phosphorylation, and LTP-dependent gene induction, resulting in rapidly decaying LTP, while being uncompetitive with respect to ATP. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration. SL-327 has also been shown to inhibit ERK1, MEK-3/p38, MEK-4, JNK, and PKC activities when used at higher concentrations.
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