Palonosetron HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 135729-62-3 | Cat. No. | BCP06204 |
| Name | Palonosetron HCl | ||
| Synonyms | Aloxi;Onicit;RS-25259-197; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H25ClN2O | M. Wt | 332.87 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Palonosetron is a highly potent, selective, second-generation 5-HT3 receptor antagonist with a 5-HT3 receptor binding affinity that is ～100-fold higher than other 5-HT3 receptor antagonists (pKi 10.5 compared with 8.91 for granisetron, 8.81 for tropisetron, 8.39 for ondansetron, 7.6 for dolasetron). Palonosetron also has an extended plasma elimination half-life of ～40 h, significantly longer than others in its class (ondansetron, 4 h; tropisetron, 7.3 h; dolasetron, 7.5 h; ranisetron, 8.9 h). | ||
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