XMD17-109
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1435488-37-1 | Cat. No. | BCP09844 |
| Name | XMD17-109 | ||
| Synonyms | XMD17109;XMD 17109; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C36H46N8O3 | M. Wt | 638.8 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In vitro: The pAP1-luciferase reporter and pRL-CMV-Renilla plasmids were co-transfected with plasmids encoding for ERK5 and constitutively active MEK5 (MEK5DD) in HEK293 cells. Cells were treated with the indicated amounts of compound 26 (XMD17-109) for 24 h, and lysates were subjected to the dual-luciferase assay. Compound 26 completely inhibited the ERK5-mediated AP1 transcriptional activity at 30 μM and had an EC50 of 4.2 ± 0.7 μM. By contrast 24 had an EC50 of >30 μM. | ||
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