Products

Cas No.Product NameDescription
186692-46-6RoscovitineRoscovitine (Seliciclib) is a potent and selective inhibitor of cyclin-dependent kinases. This agent displays higher inhibitory potency and higher selectivity compared to olomoucine.
827022-32-2Palbociclib HClPalbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
345627-80-7SNS-032 BMS-387032 is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
718630-59-2PHA-793887PHA-793887 is a novel pan-cdk inhibitor, including cdk1, cdk2, cdk4, cdk5, cdk7, and cdk9 with IC50 in the 5 to 140 nM range.
844442-38-2AT7519AT7519 is a kinase inhibitor with IC50 of 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35.
146426-40-6FlavopiridolFlavopiridol (Alvocidib) is a pan-cdk inhibitor.
602306-29-6AZD 5438AZD-5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively).
479-41-4;906748-38-7IndirubinIndirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 75 nM and 0.19 μM.
1092443-52-1BS 181BS-181 is a selective cyclin-dependent kinase inhibitor with an IC50 of 21 nM for the inhibition of CDK-activating kinase.
131740-09-5Flavopiridol hydrochlorideFlavopiridol hydrochloride is a pan-cdk inhibitor.
845714-00-3PHA-767491 PHA-767491 (CAY10572) is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.
741713-40-6R547R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases with a Ki of median 2 nM for CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1.
162011-90-7 Rofecoxib Rofecoxib(MK 966) is a potent inhibitor of the COX-2-dependent production of PGE2 in human osteosarcoma cells (IC50= 26±10 nM) and Chinese hamster ovary cells expressing human COX-2 (IC50=18±7 nM).
327036-89-5TDZD-8TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM).
1231930-82-7LY2835219;Abemaciclib ;bemaciclibLY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor
300801-52-9TG-003Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members.
1211441-98-3LEE011LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
571190-30-2PalbociclibPalbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
827022-33-3PalbociclibPD0332991 Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc.
1374639-75-4LEE011 succinateLEE011 succinate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

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PI3K/Akt/mTOR
Cell Cycle/Checkpoint
Angiogenesis/Tyrosine Kinase
Apoptosis Pathway
PARP/BET
Aurora/Ksp Pathway
MAPK Pathway
Hormone Pathay
Integrase/CCR5
Proteases/HSP90/HSP70 Pathway
Wnt/Hedgehog/Notch Pathway
Jak/Stat Pathway
Ca/cAMP/Lipid Signaling Pathway
Neuro Signaling Pathway
TGF-beta/Smad Signaling Pathway
GPCR Pathway
Ion channel Pathway
Cytochrome P450 Pathway
Others Pathway
Intermediate