Cas No.Product NameDescription
1094614-84-2BIX02188BIX02188 significantly blocks MEK5 catalytic activity with IC50 of 4.3 nM and inhibits ERK5 catalytic activity with IC50 of 0.83 μM.
606143-52-6SelumetinibSelumetinib is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
212631-79-3PD184352CI-1040 is a selective MEK inhibitor (Ki = 300 nM in vitro).
391210-10-9PD0325901PD0325901 is a selective MEK1 and MEK2 inhibitor.
1094614-85-3BIX 02189BIX02189 blocks MEK5 and ERK5 catalytic activity with IC50 values of 1.5 nM and 59 nM, respectively.
391210-00-7PD318088PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.
167869-21-8PD98059PD98059 is inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK).
869357-68-6AZD8330AZD8330 is an orally active, selective MEK inhibitor with an IC50 of 7 nM.
934660-93-2CobimetinibCobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase.
305350-87-2SL327SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively).
1173097-76-1UO126U0126 is inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
1187431-43-1GSK1120212 Trametinib is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 and 0.9 nM for MEK1 and MEK2.
606143-89-9MEK162MEK162(ARRY-162; ARRY-438162) is an oral, highly selective MEK inhibitor
913376-84-8AMG-1Met/Ron Dual Kinase Inhibitor is an inhibitor of both Met and Ron.
896720-20-0VX-11eVX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent.
1435488-37-1XMD17-109XMD17-109 is a novel, specific ERK-5 inhibitor with an EC50 4.2uM in HEK293 cells.
154039-60-8MarimastatMarimastat(BB 2516; TA2516) is a broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively).
1472624-85-37ACC27ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.
874101-00-5RO4987655RO4987655(CH-4987655) is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity.
1082948-81-9LY2584702 hydrochlorideLY-2584702 Hcl is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.

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Cell Cycle/Checkpoint
Angiogenesis/Tyrosine Kinase
Apoptosis Pathway
Aurora/Ksp Pathway
MAPK Pathway
Hormone Pathay
Proteases/HSP90/HSP70 Pathway
Wnt/Hedgehog/Notch Pathway
Jak/Stat Pathway
Ca/cAMP/Lipid Signaling Pathway
Neuro Signaling Pathway
TGF-beta/Smad Signaling Pathway
GPCR Pathway
Ion channel Pathway
Cytochrome P450 Pathway
Others Pathway